A vast panel of possibilities
Patch-clamp
Whole-cell recordings allow a precise measurement of a single cell electrical activity by detecting sub-millisecond variations in membrane potential
-
Extremely precise data on single cell physiology.
-
It can be used in any brain or spinal cord structure and allows targeted recordings of specific cell types.
-
Allow targeted pre or post synaptic manipulations specifically.
-
Essential when studying the mechanisms of action and pharmacokinetics of a compound.
Extracellular recordings
Field recordings are used to extracellularly record the activity of a population of neurons, or field potentials.
-
An acute slice is highly physiological with intact, functioning circuits.
-
Localized neuronal populations are recorded simultaneously in a given slice.
-
Faster than patch-clamp, allows for a quick screening of several compounds or doses at mid-throughput data production.
Other approaches
Our capabilities include histology/immunochemistry and pharmacology as well as optogenetics combined with electrophysiology. Manipulations can be extracellular or intracellular (when using patch-clamp).
Depending on the context, we can perform recordings on specific transgenic animal models and employ acute or chronic compound exposition.
We provide a direct access, via a unique contract with EphyX Neuroscience, to in vivo electrophysiology as well as behavioral assays performed by our partners.
