A vast panel of possibilities

At EphyX, we believe that a strong expertise in a diversity of techniques is key to ensure we can consider all the options when designing an experimental protocol. 

Patch-clamp

Whole-cell recordings allow a precise measurement of a single cell electrical activity by detecting sub-millisecond variations in membrane potential

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• Extremely precise data on single cell physiology.

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• It can be used in any brain or spinal cord structure and allows targeted recordings of specific cell types.

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• Allow targeted pre or post synaptic manipulations specifically.

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• Essential when studying the mechanisms of action and pharmacokinetics of a compound.

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Extracellular recordings

Field recordings are used to extracellularly record the activity of a population of neurons, or field potentials.

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• An acute slice is highly physiological with intact, functioning circuits.

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• Localized neuronal populations are recorded simultaneously in a given slice.

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• Faster than patch-clamp, allows for a quick screening of several compounds or doses at mid-throughput data production.

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Other approaches

Our capabilities include histology/immunochemistry and pharmacology as well as optogenetics combined with electrophysiology. Manipulations can be extracellular or intracellular (when using patch-clamp).

Depending on the context, we can perform recordings on specific transgenic animal models and employ acute or chronic compound exposition.

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We provide a direct access, via a unique contract with EphyX Neuroscience, to in vivo electrophysiology as well as behavioral assays performed by our partners.

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R&D programs

We develop our own pre-clinical programs to assess the potential of a growing pipeline of candidates to treat selected pathologies.

This programs are done in collaboration with various partners.

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More to come soon...

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