A vast panel of possibilities

At EphyX, we believe that a strong expertise in a diversity of techniques is key to ensure we can consider all the options when designing an experimental protocol. 

Patch-clamp

Whole-cell recordings allow a precise measurement of a single cell electrical activity by detecting sub-millisecond variations in membrane potential

  • Extremely precise data on single cell physiology.

  • It can be used in any brain or spinal cord structure and allows targeted recordings of specific cell types.

  • Allow targeted pre or post synaptic manipulations specifically.

  • Essential when studying the mechanisms of action and pharmacokinetics of a compound.

    

 

Extracellular recordings

Field recordings are used to extracellularly record the activity of a population of neurons, or field potentials, simultaneously in different places via its numerous electrodes.

  • An acute slice is highly physiological with intact, functioning circuits.

  • Tens of localized neuronal populations are recorded simultaneously in a given slice.

  • Faster than patch-clamp, allows for a quick screening of several compounds or doses at mid-throughput data production.

 

Other approaches

Our capabilities include molecular biology and pharmacology as well as optogenetics combined with electrophysiology. Manipulations can be extracellular or intracellular (when using patch-clamp).

 

Depending on the context, we can perform recordings on specific transgenic animal models and employ acute or chronic compound exposition.

We provide a direct access, via a unique contract with EphyX Neuroscience, to in vivo electrophysiology as well as behavioral assays performed by our partners.

 

R&D programs

A specific team is dedicated to design and develop innovative approaches to electrophysiology. These innovations cover different aspects of CNS-related research and can be developed in partnership with academic laboratories or relevant companies.

We also develop our own pre-clinical programs to assess the potential of a growing pipeline of candidates to treat selected pathologies.

More to come soon...

 

 

CONTACT

7 Allée de Chartres
33000 Bordeaux, France