A vast panel of possibilities
At EphyX, we believe that a strong expertise in a diversity of techniques is key to ensure we can consider all the options when designing an experimental protocol.
Patch-clamp
Whole-cell recordings allow a precise measurement of a single cell electrical activity by detecting sub-millisecond variations in membrane potential
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Extremely precise data on single cell physiology.
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It can be used in any brain or spinal cord structure and allows targeted recordings of specific cell types.
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Allow targeted pre or post synaptic manipulations specifically.
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Essential when studying the mechanisms of action and pharmacokinetics of a compound.
Extracellular recordings
Field recordings are used to extracellularly record the activity of a population of neurons, or field potentials, simultaneously in different places via its numerous electrodes.
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An acute slice is highly physiological with intact, functioning circuits.
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Tens of localized neuronal populations are recorded simultaneously in a given slice.
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Faster than patch-clamp, allows for a quick screening of several compounds or doses at mid-throughput data production.
Other approaches
Our capabilities include molecular biology and pharmacology as well as optogenetics combined with electrophysiology. Manipulations can be extracellular or intracellular (when using patch-clamp).
Depending on the context, we can perform recordings on specific transgenic animal models and employ acute or chronic compound exposition.
We provide a direct access, via a unique contract with EphyX Neuroscience, to in vivo electrophysiology as well as behavioral assays performed by our partners.
R&D programs
A specific team is dedicated to design and develop innovative approaches to electrophysiology. These innovations cover different aspects of CNS-related research and can be developed in partnership with academic laboratories or relevant companies.
We also develop our own pre-clinical programs to assess the potential of a growing pipeline of candidates to treat selected pathologies.
More to come soon...