A vast panel of possibilities
At EphyX, we believe that a strong expertise in a diversity of techniques is key to ensure we can consider all the options when designing an experimental protocol.
Whole-cell recordings allow a precise measurement of a single cell electrical activity by detecting sub-millisecond variations in membrane potential
Extremely precise data on single cell physiology.
It can be used in any brain or spinal cord structure and allows targeted recordings of specific cell types.
Allow targeted pre or post synaptic manipulations specifically.
Essential when studying the mechanisms of action and pharmacokinetics of a compound.
Field recordings are used to extracellularly record the activity of a population of neurons, or field potentials, simultaneously in different places via its numerous electrodes.
An acute slice is highly physiological with intact, functioning circuits.
Tens of localized neuronal populations are recorded simultaneously in a given slice.
Faster than patch-clamp, allows for a quick screening of several compounds or doses at mid-throughput data production.
Our capabilities include molecular biology and pharmacology as well as optogenetics combined with electrophysiology. Manipulations can be extracellular or intracellular (when using patch-clamp).
Depending on the context, we can perform recordings on specific transgenic animal models and employ acute or chronic compound exposition.
We provide a direct access, via a unique contract with EphyX Neuroscience, to in vivo electrophysiology as well as behavioral assays performed by our partners.
A specific team is dedicated to design and develop innovative approaches to electrophysiology. These innovations cover different aspects of CNS-related research and can be developed in partnership with academic laboratories or relevant companies.
We also develop our own pre-clinical programs to assess the potential of a growing pipeline of candidates to treat selected pathologies.
More to come soon...