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PRECLINICAL STUDIES MORE...HUMAN

IN VITRO MODELS
 

HUMAN NEURONAL CULTURES

Animal-to-human data translation is particularly poor in CNS-related pharma development.

We propose to use human neurons at preclinical stages to  ensure data reliability an limit the risk of failure.

  • IPSC-derived neurons are a relevant model in the assessment of safety and efficacy profiles of compounds.

  • In some cases, the cells may come from patient carrying a specific mutation of interest for several pathologies.

  • IPSCs can be differentiated into the most comon cell types (glutamatergic, gabaergic, dopaminergic, motor etc.)

  • Patch-clamp recordings do not take longer than on tissues from rodents.

  • Results become far more predictive.

 
 

RODENT ACUTE BRAIN SLICES

We provide dissociated cultures as well as acute slice recordings from rodents. These easy-to-use preparations present various advantages.

  • All circuits are intact and all cell types are present.

  • Alteration of circuit-specific phenomena can be studied: plasticity, gamma-oscillations, epilepsy etc.

 

  • Transgenic mouse models reliably mimic human pathologies.

  • Precise manipulations (e.g. cell-type-specificity, knock-out, optogenetics etc.) can easily be achieved by employing transgenic animals.

IN VIVO MODELS
Key partnerships covering a large spectrum of expertise

 

High-throughput EEG: Zebrafish model

Our preferred partner, Zefit, offers fast -screening of candidate compounds for CNS-related prelinical studies. 

  • Recordings of EEG signals in vivo using proprietary method.

  • Fast screening, with up to 1000 test/month.

 

  • Highly relevant zebrafish models of CNS conditions.

  • Highly qualified and expert team with state of the art equipment.

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IN VIVO RECORDINGS & BEHAVIOUR

We partner with an on-site innovative company, AQUINEURO, providing state of the art in vivo recordings and behavior analysis to complement our in vitro approach. 

  • Recordings can be done in anaesthetized or freely-moving animals.

  • After implantation of the recording electrodes, single and multi-units are obtained.

 

  • Top-quality behavioral testings and analysis are also available.

  • All experiments are designed and performed by experts in the field.