EphyX Neuroscience

Animal-to-human data translation is particularly poor in CNS-related pharma development.

We propose to use human neurons at preclinical stages to ensure data reliability an limit the risk of failure.

We provide dissociated cultures as well as acute slice recordings from rodents. These easy-to-use preparations present various advantages.

Our preferred partner, Zefit, offers fast -screening of candidate compounds for CNS-related prelinical studies.

We partner with an on-site innovative company, AQUINEURO, providing state of the art in vivo recordings and behavior analysis to complement our in vitro approach.

IPSC-derived neurons are a relevant model in the assessment of safety and efficacy profiles of compounds.

In some cases, the cells may come from patient carrying a specific mutation of interest for several pathologies.

IPSCs can be differentiated into the most comon cell types (glutamatergic, gabaergic, dopaminergic, motor etc.)

Patch-clamp recordings do not take longer than on tissues from rodents.

Results become far more predictive.

We provide dissociated cultures as well as acute slice recordings from rodents. These easy-to-use preparations present various advantages.

All circuits are intact and all cell types are present.

Alteration of circuit-specific phenomena can be studied: plasticity, gamma-oscillations, epilepsy etc.

Transgenic mouse models reliably mimic human pathologies.

Precise manipulations (e.g. cell-type-specificity, knock-out, optogenetics etc.) can easily be achieved by employing transgenic animals.

Our preferred partner, Zefit, offers fast -screening of candidate compounds for CNS-related prelinical studies.

Recordings of EEG signals in vivo using proprietary method.

Fast screening, with up to 1000 test/month.

Highly relevant zebrafish models of CNS conditions.

Highly qualified and expert team with state of the art equipment.

We partner with an on-site innovative company, AQUINEURO, providing state of the art in vivo recordings and behavior analysis to complement our in vitro approach.

Recordings can be done in anaesthetized or freely-moving animals.

After implantation of the recording electrodes, single and multi-units are obtained.

Top-quality behavioral testings and analysis are also available.

All experiments are designed and performed by experts in the field.

IPSC-derived neurons are a relevant model in the assessment of safety and efficacy profiles of compounds.

​

In some cases, the cells may come from patient carrying a specific mutation of interest for several pathologies.

​

IPSCs can be differentiated into the most comon cell types (glutamatergic, gabaergic, dopaminergic, motor etc.)

​

Patch-clamp recordings do not take longer than on tissues from rodents.

​

Results become far more predictive.

We provide dissociated cultures as well as acute slice recordings from rodents. These easy-to-use preparations present various advantages.

All circuits are intact and all cell types are present.

​

Alteration of circuit-specific phenomena can be studied: plasticity, gamma-oscillations, epilepsy etc.

Transgenic mouse models reliably mimic human pathologies.

​

Precise manipulations (e.g. cell-type-specificity, knock-out, optogenetics etc.) can easily be achieved by employing transgenic animals.

Our preferred partner, Zefit, offers fast -screening of candidate compounds for CNS-related prelinical studies.

Recordings of EEG signals in vivo using proprietary method.

​

Fast screening, with up to 1000 test/month.

Highly relevant zebrafish models of CNS conditions.

​

Highly qualified and expert team with state of the art equipment.

We partner with an on-site innovative company, AQUINEURO, providing state of the art in vivo recordings and behavior analysis to complement our in vitro approach.

Recordings can be done in anaesthetized or freely-moving animals.

​

After implantation of the recording electrodes, single and multi-units are obtained.

Top-quality behavioral testings and analysis are also available.

​

All experiments are designed and performed by experts in the field.