Pre-clinical studies more...human

We provide a clear and detailed picture of the effects of your compounds on neuronal physiology, from circuits down to single ion channels.

Recording from human cells at preclinical stages provides a unique opportunity to optimize compounds' selection and drastically limit the risk of failure.

Human iPSCs-derived neurons

Animal-to-human data translation is particularly poor in CNS-related pharma development.

We propose to use human neurons at preclinical stages to  ensure data reliability an limit the risk of failure.

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• IPSC-derived neurons are a relevant model in the assessment of safety and efficacy profiles of compounds.

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• In some cases, the cells may come from patient carrying a specific mutation of interest for several pathologies.

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• IPSCs can be differentiated into the most comon cell types (glutamatergic, gabaergic, dopaminergic, motor etc.)

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• Patch-clamp recordings do not take longer than on tissues from rodents.

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• Results become far more predictive.

Rodent acute slices

We provide dissociated cultures as well as acute slice recordings from rodents. These easy-to-use preparations present various advantages.

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• All circuits are intact and all cell types are present.

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• Alteration of circuit-specific phenomena can be studied: plasticity, gamma-oscillations, epilepsy etc.

• Transgenic mouse models reliably mimic human pathologies.

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• Precise manipulations (e.g. cell-type-specificity, knock-out, optogenetics etc.) can easily be achieved by employing transgenic animals.

IN VIVO 

We partner with an on-site innovative company providing state of the art in vivo recordings and behavior analysis to complement our in vitro approach. 

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• Recordings can be done in anaesthetized or freely-moving animals

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• After implantation of the recording electrodes, single and multi-units are obtained.

• Top-quality behavioral testings and analysis are also available.

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• All experiments are designed and performed by experts in the field.