Pre-clinical studies more...human
Human iPSCs-derived neurons
Animal-to-human data translation is particularly poor in CNS-related pharma development.
We propose to use human neurons at preclinical stages to ensure data reliability an limit the risk of failure.
-
IPSC-derived neurons are a relevant model in the assessment of safety and efficacy profiles of compounds.
-
In some cases, the cells may come from patient carrying a specific mutation of interest for several pathologies.
-
IPSCs can be differentiated into the most comon cell types (glutamatergic, gabaergic, dopaminergic, motor etc.)
-
Patch-clamp recordings do not take longer than on tissues from rodents.
-
Results become far more predictive.
Rodent acute slices
We provide dissociated cultures as well as acute slice recordings from rodents. These easy-to-use preparations present various advantages.
-
All circuits are intact and all cell types are present.
-
Alteration of circuit-specific phenomena can be studied: plasticity, gamma-oscillations, epilepsy etc.
-
Transgenic mouse models reliably mimic human pathologies.
-
Precise manipulations (e.g. cell-type-specificity, knock-out, optogenetics etc.) can easily be achieved by employing transgenic animals.
IN VIVO
We partner with an on-site innovative company providing state of the art in vivo recordings and behavior analysis to complement our in vitro approach.
-
Recordings can be done in anaesthetized or freely-moving animals
-
After implantation of the recording electrodes, single and multi-units are obtained.
-
Top-quality behavioral testings and analysis are also available.
-
All experiments are designed and performed by experts in the field.